BL day of OGTT

Phase 1: baseline day of OGTT (Oral Glucose Tolerance Test)

Integer

BL month of OGTT

Phase 1: baseline month of OGTT

Integer

BL year of OGTT

Phase 1: baseline year of OGTT (Oral Glucose Tolerance test)

Integer

FUP fasting insulin

Phase 2: Insulin measurement at fasting blood sample?

Integer

FUP 120 min insulin

Phase 2: Insulin measurement at 30 mins after glucose sample?

Integer

FUP 30 min insulin

Phase 2: Insulin measurement at 120 mins after glucose sample?

Integer

FUP insulin AUC

Phase 2: Unclear what this variable relates to. Follow-up insulin AUC?

Real

FUP 30 min insulin increment

Phase 2: 30 minute insulin increment

Real

FUP fasting plasma glucose (mmol/l)

Phase 2: Plasma glucose measurement at fasting blood sample in mmol/l

mmol/l

Real

FUP 120 min plasma glucose (mmol/l)

Phase 2: Plasma glucose measurement at 120 mins after glucose sample in mmol/l

mmol/l

Real

FUP 30 min plasma glucose (mmol/l)

Phase 2: Plasma glucose measurement at 30 mins after glucose sample in mmol/l

mmol/l

Real

FUP PG AUC

Phase 2: Related to plasma glucose

Real

FUP fasting intact proinsulin

Phase 2: Participant's baseline fasting intact proinsulin at Phase 2 in pmol/l

pmol/l

Real

FUP fasting 32,33 split proinsulin

Phase 2: follow-up fasting 32,33 split proinsulin (pmol/l)

pmol/l

Real

P3 Fasting glucose

Phase 3: fasting glucose (fresh plasma) in mmol/l

mmol/l

Real

P3 fasting glucose

Phase 3: fasting glucose (venous whole blood) in mmol/l

mmol/l

Real

P3 120 min Glucose

Phase 3: 120 minute glucose (fresh plasma) in mmol/l

mmol/l

Real

P3 120min glucose

Phase 3: 2 hr glucose (venous whole blood) in mmol/l

mmol/l

Real

P3 30min Glucose

Phase 3: 30min glucose (fresh plasma) in mmol/l

mmol/l

Real

P3 60min glucose

Phase 3: 60min glucose (fresh plasma) in mmol/l

mmol/l

Real

fasting insulin (pmol/l) at P3

Phase 3: fasting insulin (pmol/l) at phase III

pmol/l

Integer

120 min insulin (pmol/l) at P3

Phase 3: 120 min insulin (pmol/l) at phase III

pmol/l

Real

30 min insulin (pmol/l) at P3

Phase 3: 30 min insulin (pmol/l) at phase III

pmol/l

Real

60 min insulin (pmol/l) at P3

Phase 3: 60 min insulin (pmol/l) at phase III

pmol/l

Real

30 min insulin increment

Phase 3: 30 min insulin increment

Real

paracetamol test done

Phase 1: paracetamol test done. The paracetamol test is carried out to examine whether the ratio of sulphated / glucorinated breakdown products of paracetamol is associated with glucose intolerance. 2 Tablets are taken at 10 pm on the night before they come to the clinic for the glucose test where they need to provide a urine sample. 0 = ; no; 1 = yesno, 1 = yes

Categorical

fasting glucose (mmol/l) at P3 (frozen)

Phase 3: fasting glucose (mmol/l) at phase 3 (frozen)

mmol/l

Real

120minose at P3

Phase 3: 120 min glucose (mmol/l) at phase 3 (frozen)

mmol/l

Real

30min glucose at P3

Phase 3: 30 min glucose (mmol/l) at phase 3 (frozen)

mmol/l

Real

60 min glucose (mmol/l) at P3 (frozen)

Phase 3: 60 min glucose (mmol/l) at phase 3 (frozen)

mmol/l

Real

proinsulin at P3

Phase 3: proinsulin reading (pmol/l) at phase 3

pmol/l

Real

split insulin (pmol/l) at P3

Phase 3: split insulin (pmol/l) at phase 3

pmol/l

Real